Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is considered a high grade Non-Hodgkin’s Lymphoma (NHL) characterized by aggressive systemic disease. ALCL most commonly arises in children and young adults involving clonal expansion of T-cells.
FISH Assays:
ALK-BA: ALK translocations are observed in ~60% of ALCL cases. The most common fusion is NPM-ALK. Clinical trials for the treatment of ALCL with Crizotinib are being conducted.1
References
- Duyster J, Bai RY, Morris SW. Translocations involving anaplastic lymphoma kinase (ALK). Oncogene. 2001 Sep 10;20(40):5623-37. Review. PubMed PMID: 11607814.