Bladder Cancer
Standard of care for the detection bladder cancer is cytological evaluation of cell morphology and the FDA approved UroVysion assay.
FISH Assays:
Aneuploidy: Copy number increases of chromosomes 3, 7, and 17 are associated with bladder cancer.
p16 (9p21): Deletion of 9p21 (p16) is associated with bladder cancer.
References
- Skacel M, Fahmy M, Brainard JA, Pettay JD, Biscotti CV, Liou LS, Procop GW, Jones JS, Ulchaker J, Zippe CD, Tubbs RR.: Multitarget fluorescence in situ hybridization assay detects transitional cell carcinoma in the majority of patients with bladder cancer and atypical or negative urine cytology. J Urol. 2003 Jun;169(6):2101-5.